English: Arms of Newton of Mickleover, Derbyshire. Arms of Newton of Horsley and Mickleover, Derbyshire. Descended from Newton of Newton, Cheshire, which family settled at Horsley circa 1500. The senior line of Newton of Duffield died out but a junior line Newton of Mickleover, Derbyshire, continued until 1789, when the estates devolved on John Leaper who assumed by sign manual the additional name of Newton and the arms of Newton: Sable, two human shinbones in saltire proper/argent (Burke, Sir Bernard, The General Armory, London, 1884, p.731).

Coat of arms of Sir Isaac Newton (see e.g. Gérard P. Michon Escutcheons of Science - Armorial of Scientists - Numericana). Isaac Newton was granted the right to bear a coat of arms by the College of Heralds in 1705; this was not in recognition of his contributions to science, but rather a political favour to his patron, Lord Halifax. Newton had to submit a genealogy to the College of Heralds, where he claimed a shared male line descent with Sir John Newton, 3rd Baronet of Barrs Court in the County of Gloucester Modern genealogical scholarship confirms that they were third cousins (see Foster, C. W. (1928). "Sir Isaac Newton's Family". Reports and Papers of the Architectural and Archaeological Societies of the County of Lincoln, etc. 39 (1): 1–62). Therefore the coat of arms granted to him by the College of Heralds was the same as that borne by the Newton baronet: Sable, two shin-bones in saltire argent, the dexter surmounted of the sinister. (answers.com)

Text from: History of Woolsthorpe, 2016[1]:

• By the 13th century Woolsthorpe was a separate manor known as Mortimers Manor. It passed down through the ages belonging to various families of note the Sleafords, the Pigotts, the Thimelbys, the Burys and the Underwoods, who in 1623 sold it to Robert Newton, grandfather of Sir Isaac Newton (1642-1727), the scientist. It was the Newton familys second property in Woolsthorpe and Robert then settled it on his son Isaac Newton (d.1642), father of Sir Isaac Newton, as a wedding dowry in 1639. In April 1642 Isaac married Hannah Ayscough, a daughter of James Ayscough by his wife Margery Blyth, a daughter of William Blyth. With the manor went the title Lord of the Manor, also possibly the ancient rites of Court Manor and Court Leet, together with most of the property, workers and land within the hamlet. The Newtons were sheep farmers but sadly Isaac died in October 1642 aged only 36yrs. Their son (Sir Isaac Newton) was born prematurely on 25th December 1642 (Julian Calendar); he was small and sickly and not expected to survive; he was named Isaac after his father. He spent his childhood growing up at Woolsthorpe Manor, being brought up mainly by his maternal grand mother Margery Blyth, of the Blythe family of Stroxton, Linconshire. His mother re-married and went to live at North Witham with her second husband, Rev Barnabas Smith.